Tolerance to the effects of daily nicotine on rat bar pressing behavior for water reinforcement.
نویسندگان
چکیده
DOMINO, E. F. AND M. P. LUTZ. Tolerance to the effects of daily nicotine on rat bar pressing behavior for water reinforcement. PHARMAC, BIOCHEM. BEHAV. 1(4) 445-448, 1973.-The effects of daily nicotine tartrate given IP in a dose of 0.25 mg/kg twice a day for 15 days was studied on bar pressing behavior for water reinforcement in the rat. A modified FR t 5 schedule was used. Nicotine injections caused an initial disruption of bar pressing behavior with rapid tolerance development. Antidiuretic hormone (5-10 units/kg, SC) administration also suppressed water drinking behavior after an initial latency in contrast to the effects of nicotine. It is concluded that tolerance occurs to daily nicotine administration.
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ورودعنوان ژورنال:
- Pharmacology, biochemistry, and behavior
دوره 1 4 شماره
صفحات -
تاریخ انتشار 1973